Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chronic ethanol consumption increases myocardial mitochondrial DNA mutations: a potential contribution by mitochondrial topoisomerases.

Alcohol and alcoholism (Oxford, Oxfordshire) - 1 Jan 2000

Laurent D, Mathew J E, Mitry M, Taft M, Force A, Edwards J G

Abstract excerpt

AIMS: Alcoholic cardiomyopathy (ACM) presents as decreased myocardial contractility, arrhythmias and secondary non-ischemic dilated cardiomyopathy leading to heart failure. Mitochondrial dysfunction is known to have a significant role in the development and complications of ACM. This study investigated if chronic ethanol feeding promoted myocardial mitochondrial topoisomerase dysfunction as one underlying cause...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Drinking
Share to Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Damage

Share to DNA, Mitochondrial

Share to Electron Transport Complex IV

Share to Myocardium

Source

Open in PubMed Open full text

Identifiers

PMID: 24852753
DOI: 10.1093/alcalc/agu029
PMCID: PMC4060737

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chronic ethanol consumption increases myocardial mitochondrial DNA mutations: a potential contribution by mitochondrial topoisomerases.PMID 24852753Read ↗

Alcohol exposure during pregnancy induces cardiac mitochondrial damage in offspring miceSemantic proximity Read ↗

Alcoholic Cardiomyopathy: Disrupted Protein Balance and Impaired Cardiomyocyte ContractilitySemantic proximity Read ↗

Type II diabetes increases mitochondrial DNA mutations in the left ventricle of the Goto-Kakizaki diabetic rat.Semantic proximity Read ↗

Alteration of cardiac energetics and mitochondrial function in doxorubicin‑induced cardiotoxicity: Molecular mechanism and prospective implications (Review)Semantic proximity Read ↗

Review on the Role of Epigenetic Modifications in Doxorubicin-Induced CardiotoxicitySemantic proximity Read ↗

Time-Dependent and Tissue-Specific Accumulation of mtDNA and Respiratory Chain Defects in Chronic Doxorubicin CardiomyopathySemantic proximity Read ↗

Genetic Etiology for Alcohol-Induced Cardiac Toxicity.Semantic proximity Read ↗

Angiotensin-converting enzyme gene polymorphism is associated with vulnerability to alcoholic cardiomyopathy.Semantic proximity Read ↗

Metformin alleviates ethanol-induced cardiomyocyte injury by activating AKT/Nrf2 signaling in an ErbB2-dependent mannerSemantic proximity Read ↗

Tissue‐specific mtDNA lesions and radical‐associated mitochondrial dysfunction in human hearts exposed to doxorubicinSemantic proximity Read ↗

Loss of DNA repair mechanisms in cardiac myocytes induce dilated cardiomyopathySemantic proximity Read ↗

Elamipretide Improves Mitochondrial Function in the Failing Human HeartSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.