Genetic Etiology for Alcohol-Induced Cardiac Toxicity.

doi:10.1016/j.jacc.2018.03.462

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Article

Genetic Etiology for Alcohol-Induced Cardiac Toxicity.

Journal of the American College of Cardiology - 22 May 2018

Ware James S, Amor-Salamanca Almudena, Tayal Upasana, Govind Risha, Serrano Isabel, Salazar-Mendiguchía Joel, García-Pinilla Jose Manuel, Pascual-Figal Domingo A, Nuñez Julio, Guzzo-Merello Gonzalo, Gonzalez-Vioque Emiliano, Bardaji Alfredo, Manito Nicolas, López-Garrido Miguel A, Padron-Barthe Laura, Edwards Elizabeth, Whiffin Nicola, Walsh Roddy, Buchan Rachel J, Midwinter William, Wilk Alicja, Prasad Sanjay, Pantazis Antonis, Baski John, O'Regan Declan P, Alonso-Pulpon Luis, Cook Stuart A, Lara-Pezzi Enrique, Barton Paul J, Garcia-Pavia Pablo

Abstract excerpt

BACKGROUND: Alcoholic cardiomyopathy (ACM) is defined by a dilated and impaired left ventricle due to chronic excess alcohol consumption. It is largely unknown which factors determine cardiac toxicity on exposure to alcohol. OBJECTIVES: This study sought to evaluate the role of variation in cardiomyopathy-associated genes in the pathophysiology of ACM, and to examine the effects of alcohol intake and genotype on...

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PMID: 29773157
DOI: 10.1016/j.jacc.2018.03.462
PMCID: PMC5957753

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