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Article

Type II diabetes increases mitochondrial DNA mutations in the left ventricle of the Goto-Kakizaki diabetic rat.

American journal of physiology. Heart and circulatory physiology - 1 Apr 2013

Hicks S, Labinskyy N, Piteo B, Laurent D, Mathew J E, Gupte S A, Edwards J G

Abstract excerpt

Mitochondrial dysfunction has a significant role in the development of diabetic cardiomyopathy. Mitochondrial oxidant stress has been accepted as the singular cause of mitochondrial DNA (mtDNA) damage as an underlying cause of mitochondrial dysfunction. However, separate from a direct effect on mtDNA integrity, diabetic-induced increases in oxidant stress alter mitochondrial topoisomerase function to propagate...

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Identifiers

PMID: 23376826
DOI: 10.1152/ajpheart.00567.2012
PMCID: PMC3625896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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