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Article

Elamipretide Improves Mitochondrial Function in the Failing Human Heart

1 Apr 2019

Abstract excerpt

• Mitochondrial function is impaired in explanted failing pediatric and adult human hearts. • Elamipretide is a novel mitochondria-targeted drug that is targeted to cardiolipin on the inner mitochondrial membrane and improves coupling of the electron transport chain. • Treatment of explanted human hearts with elamipretide improves human cardiac mitochondrial function. • The study provides novel methods to...

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Share to ATP Synthase and ATPases Research
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Identifiers

PMID: 31061916
DOI: 10.1016/j.jacbts.2018.12.005

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