Article
Angiotensin-converting enzyme gene polymorphism is associated with vulnerability to alcoholic cardiomyopathy.
Annals of internal medicine - 3 Sept 2002
Fernández-Solà Joaquim, Nicolás Josep María, Oriola Josep, Sacanella Emilio, Estruch Ramón, Rubin Emanuel, Urbano-Márquez Alvaro
Abstract excerpt
BACKGROUND: Chronic alcohol abuse has a dose-dependent toxic effect on the myocardium, leading to alcoholic cardiomyopathy. The fact that only a minority of persons with chronic alcoholism have this condition suggests the possibility of a genetic vulnerability. In this context, polymorphism of the angiotensin-converting enzyme (ACE) gene has been implicated in cardiac dysfunction. OBJECTIVE: To compare the ACE...
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