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Article

Anti-ApoE antibody given after plaque onset decreases Aβ accumulation and improves brain function in a mouse model of Aβ amyloidosis.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 21 May 2014

Liao Fan, Hori Yukiko, Hudry Eloise, Bauer Adam Q, Jiang Hong, Mahan Thomas E, Lefton Katheryn B, Zhang Tony J, Dearborn Joshua T, Kim Jungsu, Culver Joseph P, Betensky Rebecca, Wozniak David F, Hyman Bradley T, Holtzman David M

Abstract excerpt

Apolipoprotein E (apoE) is the strongest known genetic risk factor for late onset Alzheimer's disease (AD). It influences amyloid-β (Aβ) clearance and aggregation, which likely contributes in large part to its role in AD pathogenesis. We recently found that HJ6.3, a monoclonal antibody against ap...

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Identifiers

PMID: 24849360
DOI: 10.1523/JNEUROSCI.0646-14.2014
PMCID: PMC4028501

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APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24849360-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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