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Article

Fullerenol Protects Retinal Pigment Epithelial Cells From Oxidative Stress–Induced Premature Senescence via Activating SIRT1

20 May 2014

Abstract excerpt

PURPOSE: Oxidative stress-induced retinal pigment epithelium (RPE) senescence is one of the important factors in the pathogenesis of age-related macular degeneration (AMD). This study aimed to develop a new antisenescence-based intervention and clarify its possible molecular mechanism. METHODS: A cell premature senescence model was established in both primary RPE cells and ARPE-19 cells by exposure of the cells...

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PMID: 24845634
DOI: 10.1167/iovs.13-13732

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