Article

Lutein suppresses hyperglycemia‐induced premature senescence of retinal pigment epithelial cells by upregulating SIRT1

2018-06-01

Abstract excerpt

Hyperglycemia contributes to the pathogenesis of diabetic complications, such as diabetic retinopathy, by affecting cellular redox state. In this study, we investigated the effects of lutein on hyperglycemia‐induced premature senescence in retinal pigment epithelium (RPE) cells. In ARPE‐19 cells, a spontaneously immortalized cell line derived from human RPE, lutein treatment significantly inhibited high glucose‐tr...

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Literature Corpus work: 733e1ccf-0f68-5b66-b4cd-f2d9e01dc790
DOI: 10.1111/jfbc.12495

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