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Article

Small molecular antioxidants effectively protect from PUVA-induced oxidative stress responses underlying fibroblast senescence and photoaging.

Free radical biology & medicine - 1 Sept 2008

Briganti Stefania, Wlaschek Meinhard, Hinrichs Christina, Bellei Barbara, Flori Enrica, Treiber Nicolai, Iben Sebastian, Picardo Mauro, Scharffetter-Kochanek Karin

Abstract excerpt

Exposure of human fibroblasts to 8-methoxypsoralen plus ultraviolet-A irradiation (PUVA) results in stress-induced cellular senescence in fibroblasts. We here studied the role of the antioxidant defense system in the accumulation of reactive oxygen species (ROS) and the effect of the antioxidants alpha-tocopherol, N-acetylcysteine, and alpha-lipoic acid on PUVA-induced cellular senescence. PUVA treatment induced...

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Source

Identifiers

PMID: 18538675
DOI: 10.1016/j.freeradbiomed.2008.05.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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