Article
Gene-lifestyle interaction and type 2 diabetes: the EPIC interact case-cohort study.
PLoS medicine - 1 May 2014
Langenberg Claudia, Sharp Stephen J, Franks Paul W, Scott Robert A, Deloukas Panos, Forouhi Nita G, Froguel Philippe, Groop Leif C, Hansen Torben, Palla Luigi, Pedersen Oluf, Schulze Matthias B, Tormo Maria-Jose, Wheeler Eleanor, Agnoli Claudia, Arriola Larraitz, Barricarte Aurelio, Boeing Heiner, Clarke Geraldine M, Clavel-Chapelon Françoise, Duell Eric J, Fagherazzi Guy, Kaaks Rudolf, Kerrison Nicola D, Key Timothy J, Khaw Kay Tee, Kröger Janine, Lajous Martin, Morris Andrew P, Navarro Carmen, Nilsson Peter M, Overvad Kim, Palli Domenico, Panico Salvatore, Quirós J Ramón, Rolandsson Olov, Sacerdote Carlotta, Sánchez María-José, Slimani Nadia, Spijkerman Annemieke M W, Tumino Rosario, van der A Daphne L, van der Schouw Yvonne T, Barroso Inês, McCarthy Mark I, Riboli Elio, Wareham Nicholas J
Abstract excerpt
BACKGROUND: Understanding of the genetic basis of type 2 diabetes (T2D) has progressed rapidly, but the interactions between common genetic variants and lifestyle risk factors have not been systematically investigated in studies with adequate statistical power. Therefore, we aimed to quantify the combined effects of genetic and lifestyle factors on risk of T2D in order to inform strategies for prevention. METHODS...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.