Article
Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study.
Diabetologia - 1 Sept 2011
Langenberg C, Sharp S, Forouhi N G, Franks P W, Schulze M B, Kerrison N, Ekelund U, Barroso I, Panico S, Tormo M J, Spranger J, Griffin S, van der Schouw Y T, Amiano P, Ardanaz E, Arriola L, Balkau B, Barricarte A, Beulens J W J, Boeing H, Bueno-de-Mesquita H B, Buijsse B, Chirlaque Lopez M D, Clavel-Chapelon F, Crowe F L, de Lauzon-Guillan B, Deloukas P, Dorronsoro M, Drogan D, Froguel P, Gonzalez C, Grioni S, Groop L, Groves C, Hainaut P, Halkjaer J, Hallmans G, Hansen T, Huerta Castaño J M, Kaaks R, Key T J, Khaw K T, Koulman A, Mattiello A, Navarro C, Nilsson P, Norat T, Overvad K, Palla L, Palli D, Pedersen O, Peeters P H, Quirós J R, Ramachandran A, Rodriguez-Suarez L, Rolandsson O, Romaguera D, Romieu I, Sacerdote C, Sánchez M J, Sandbaek A, Slimani N, Sluijs I, Spijkerman A M W, Teucher B, Tjonneland A, Tumino R, van der A D L, Verschuren W M M, Tuomilehto J, Feskens E, McCarthy M, Riboli E, Wareham N J
Abstract excerpt
AIMS/HYPOTHESIS: Studying gene-lifestyle interaction may help to identify lifestyle factors that modify genetic susceptibility and uncover genetic loci exerting important subgroup effects. Adequately powered studies with prospective, unbiased, standardised assessment of key behavioural factors for gene-lifestyle studies are lacking. This case-cohort study aims to investigate how genetic and potentially modifiable...
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