Article
The link between family history and risk of type 2 diabetes is not explained by anthropometric, lifestyle or genetic risk factors: the EPIC-InterAct study.
Diabetologia - 1 Jan 2013
Scott R A, Langenberg C, Sharp S J, Franks P W, Rolandsson O, Drogan D, van der Schouw Y T, Ekelund U, Kerrison N D, Ardanaz E, Arriola L, Balkau B, Barricarte A, Barroso I, Bendinelli B, Beulens J W J, Boeing H, de Lauzon-Guillain B, Deloukas P, Fagherazzi G, Gonzalez C, Griffin S J, Groop L C, Halkjaer J, Huerta J M, Kaaks R, Khaw K T, Krogh V, Nilsson P M, Norat T, Overvad K, Panico S, Rodriguez-Suarez L, Romaguera D, Romieu I, Sacerdote C, Sánchez M J, Spijkerman A M W, Teucher B, Tjonneland A, Tumino R, van der A D L, Wark P A, McCarthy M I, Riboli E, Wareham N J
Abstract excerpt
AIMS/HYPOTHESIS: Although a family history of type 2 diabetes is a strong risk factor for the disease, the factors mediating this excess risk are poorly understood. In the InterAct case-cohort study, we investigated the association between a family history of diabetes among different family members and the incidence of type 2 diabetes, as well as the extent to which genetic, anthropometric and lifestyle risk...
Topics
- Adult
- Aged
- Aged, 80 and over
- Body Mass Index
- Case-Control Studies
- Cohort Studies
- Cross-Sectional Studies