Interactions between genetic predisposition to obesity, insulin resistance and type 2 diabetes risk, and food or beverage intake for incident type 2 diabetes: European Prospective Investigation into Cancer and Nutrition (EPIC) InterAct case-cohort study.

doi:10.1016/j.ajcnut.2026.101198

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Interactions between genetic predisposition to obesity, insulin resistance and type 2 diabetes risk, and food or beverage intake for incident type 2 diabetes: European Prospective Investigation into Cancer and Nutrition (EPIC) InterAct case-cohort study.

The American journal of clinical nutrition - 1 Mar 2026

Li Sherly X, Imamura Fumiaki, Sharp Stephen J, Schulze Matthias B, Zheng Ju-Sheng, Amiano Pilar, Ardanaz Eva, Bergmann Manuela M, Chirlaque Maria-Dolores, Fagherazzi Guy, Franks Paul W, Grioni Sara, Ibsen Daniel B, Jakszyn Paula, Johansson Ingegerd, Katzke Verena A, Laouali Nasser, Mancini Francesca R, Overvad Kim, Palli Domenico, Panico Salvatore, Redondo-Sánchez Daniel, Ricceri Fulvio, Rolandsson Olov, Srour Bernard, Tjønneland Anne, Tong Tammy Yn, van der Schouw Yvonne T, Riboli Elio, Langenberg Claudia, Forouhi Nita G, Wareham Nick J

Abstract excerpt

BACKGROUND: Limited evidence exists for effect modification of genetic characteristics on the associations of food consumption and incident type 2 diabetes (T2D). OBJECTIVES: We aimed to investigate whether the food-T2D association would vary by genetic susceptibility to metabolic traits. METHODS: We analyzed data from 9542 incident T2D cases and a subcohort of 12,477 participants nested within the...

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PMID: 41548598
DOI: 10.1016/j.ajcnut.2026.101198
PMCID: PMC12975352

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