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Article

Multiomics reveals persistence of obesity-associated immune cell phenotypes in adipose tissue during weight loss and weight regain in mice.

Nature communications - 26 May 2022

Cottam Matthew A, Caslin Heather L, Winn Nathan C, Hasty Alyssa H

Abstract excerpt

Within adipose tissue (AT), immune cells and parenchymal cells closely interact creating a complex microenvironment. In obesity, immune cell derived inflammation contributes to insulin resistance and glucose intolerance. Diet-induced weight loss improves glucose tolerance; however, weight regain further exacerbates the impairment in glucose homeostasis observed with obesity. To interrogate the immunometabolic...

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Identifiers

PMID: 35618862
DOI: 10.1038/s41467-022-30646-4
PMCID: PMC9135744

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