Article
Congenic mapping and allele-specific alteration analysis of Stmm1 locus conferring resistance to early-stage chemically induced skin papillomas.
PloS one - 1 Jan 2014
Okumura Kazuhiro, Saito Megumi, Isogai Eriko, Miura Ikuo, Wakana Shigeharu, Kominami Ryo, Wakabayashi Yuichi
Abstract excerpt
Genome-wide association studies have revealed that many low-penetrance cancer susceptibility loci are located throughout the genome; however, a very limited number of genes have been identified so far. Using a forward genetics approach to map such loci in a mouse skin cancer model, we previously identified strong genetic loci conferring resistance to early-stage chemically induced skin papillomas on chromosome 7...
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