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Article

Penicillin-binding protein 2x of Streptococcus pneumoniae: the mutation Ala707Asp within the C-terminal PASTA2 domain leads to destabilization.

Microbial drug resistance (Larchmont, N.Y.) - 1 Jun 2014

Schweizer Inga, Peters Katharina, Stahlmann Christoph, Hakenbeck Regine, Denapaite Dalia

Abstract excerpt

Streptococcus pneumoniae penicillin-binding protein 2x (PBP2x) is an enzyme involved in the last stages of peptidoglycan assembly and essential for bacterial growth and survival. PBP2x localizes to the division site, a process that depends on its Penicillin-Binding Protein And Serine-Threonine-kinase Associated (PASTA) domains, which was previously demonstrated via GFP-PBP2x in living cells. During this study a...

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Identifiers

PMID: 24841912
DOI: 10.1089/mdr.2014.0082
PMCID: PMC4050470

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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