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Article

Identification of a structural determinant for resistance to β-lactam antibiotics in Gram-positive bacteria

10 Nov 1998

Abstract excerpt

Streptococcus pneumoniae is the main causal agent of pathologies that are increasingly resistant to antibiotic treatment. Clinical resistance of S. pneumoniae to beta-lactam antibiotics is linked to multiple mutations of high molecular mass penicillin-binding proteins (H-PBPs), essential enzymes involved in the final steps of bacterial cell wall synthesis. H-PBPs from resistant bacteria have a reduced affinity...

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Share to Antibiotic Resistance in Bacteria
Share to Antibiotics Pharmacokinetics and Efficacy
Share to Pneumonia and Respiratory Infections

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PMID: 9811812
DOI: 10.1073/pnas.95.23.13403

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Identification of a structural determinant for resistance to β-lactam antibiotics in Gram-positive bacteriaPMID 9811812Read ↗

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