Article
Five independent combinations of mutations can result in low-affinity penicillin-binding protein 2x of Streptococcus pneumoniae.
Journal of bacteriology - 1 Nov 1991
Laible G, Hakenbeck R
Abstract excerpt
Penicillin-binding protein 2x (PBP 2x) of Streptococcus pneumoniae is one of the high-molecular-weight PBPs involved in the development of intrinsic beta-lactam resistance. Point mutations in the PBP 2x genes (pbpX) have now been characterized in five independent spontaneous laboratory mutants in...
Topics
- Bacterial Proteins
- Base Sequence
- Carrier Proteins
- Cefotaxime
- Deoxyribonucleotides
- Drug Resistance, Microbial
- Electrophoresis, Polyacrylamide Gel
- Hexosyltransferases
- Molecular Sequence Data
- Muramoylpentapeptide Carboxypeptidase
- Mutation
- Penicillin-Binding Proteins
- Penicillins
- Peptidyl Transferases
- Streptococcus pneumoniae