Article
Identification of mutations in the prostaglandin transporter gene SLCO2A1 and phenotypic comparison between two subtypes of primary hypertrophic osteoarthropathy (PHO): A single-center study.
Bone - 1 Jan 2018
Hou Yanfang, Lin Yuanyuan, Qi Xuan, Yuan Lu, Liao Ruoxi, Pang Qianqian, Cui Lijia, Jiang Yan, Wang Ou, Li Mei, Dong Jin, Xia Weibo
Abstract excerpt
Primary hypertrophic osteoarthropathy (PHO) is an inherited disease characterized by digital clubbing, periostosis, and pachydermia. Based on two causative genes, hydroxyprostaglandin dehydrogenase (HPGD) and solute carrier organic anion transporter family member 2A1 (SLCO2A1), PHO is categorized into two subtypes: hypertrophic osteoarthropathy, primary, autosomal recessive 1 (PHOAR1) and hypertrophic...
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