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Article

Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis.

PloS one - 2 Nov 2010

Laukens Debby, Georges Michel, Libioulle Cécile, Sandor Cynthia, Mni Myriam, Vander Cruyssen Bert, Peeters Harald, Elewaut Dirk, De Vos Martine

Abstract excerpt

BACKGROUND: A multicenter genome-wide association scan for Crohn's Disease (CD) has recently reported 40 CD susceptibility loci, including 29 novel ones (19 significant and 10 putative). To gain insight into the genetic overlap between CD and ankylosing spondylitis (AS), these markers were tested for association in AS patients. PRINCIPAL FINDINGS: Two previously established associations, namely with the MHC and...

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Share to Crohn Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 21072187
DOI: 10.1371/journal.pone.0013795
PMCID: PMC2970560

Genes

ORMDL3
ICOSLG
MST1
PTPN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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