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Article

Optogenetic activation of serotonergic neurons enhances anxiety-like behaviour in mice.

The international journal of neuropsychopharmacology - 1 Nov 2014

Ohmura Yu, Tanaka Kenji F, Tsunematsu Tomomi, Yamanaka Akihiro, Yoshioka Mitsuhiro

Abstract excerpt

Whether increased serotonin (5-HT) release in the forebrain attenuates or enhances anxiety has been controversial for over 25 yr. Although there is considerable indirect evidence, there is no direct evidence that indicates a relationship between acute 5-HT release and anxiety. In particular, there is no known method that can reversibly, selectively, and temporally control serotonergic activity. To address this...

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Identifiers

PMID: 24834486
DOI: 10.1017/S1461145714000637

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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