Article

Intranasal Delivery of shRNA to Knockdown the 5HT-2A receptor Enhances Memory and Alleviates Anxiety

2023-12-27

Abstract excerpt

Short-hairpin RNAs (shRNA) targeting knockdown of specific genes hold enormous promise for precision-based therapeutics to treat numerous neurodegenerative disorders. However, whether shRNA constructed molecules can modify neuronal circuits underlying certain behaviors has not been explored. We designed shRNA to knockdown the human HTR2A gene in vitro using iPSC-differentiated neurons. Multi-electrode array (MEA...

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Literature Corpus work: e4a8063e-11f3-526d-8ca3-7176c0be1fd6
DOI: 10.1101/2023.12.27.573449

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Intranasal Delivery of shRNA to Knockdown the 5HT-2A receptor Enhances Memory and Alleviates AnxietyDOI 10.1101/2023.12.27.573449Read

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