Article

Brainwide mapping of endogenous serotonergic transmission via chemogenetic-fMRI

2017-04-03

Abstract excerpt

<h4>ABSTRACT</h4> Serotonergic transmission affects behaviours and neuro-physiological functions via the orchestrated recruitment of distributed neural systems. It is however unclear whether serotonin’s modulatory effect entails a global regulation of brainwide neural activity, or is relayed and encoded by a set of primary functional substrates. Here we combine DREADD-based chemogenetics and mouse fMRI, an approa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6478119b-c81b-587b-9970-06e7fcddd8ec
DOI: 10.1101/122770

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Brainwide mapping of endogenous serotonergic transmission via chemogenetic-fMRIDOI 10.1101/122770Read

Serotonin regulation of behaviour via large-scale neuromodulation of serotonin receptor networksSemantic proximity Read

Nucleus raphe magnus serotonin neurons bidirectionally control spinal nociceptive transmission in miceSemantic proximity Read

Functional Analysis of Distinct Populations of Subthalamic Nucleus Neurons on Parkinson’s Disease and OCD-like Behaviors in MiceSemantic proximity Read

Multiscale single-cell analysis reveals unique phenotypes of raphe 5-HT neurons projecting to the forebrain.Semantic proximity Read

A suite of engineered mice for interrogating psychedelic drug actionsSemantic proximity Read

Whole-Brain opto-fMRI Map of Mouse VTA Dopaminergic Activation Reflects Structural Projections with Small but Significant DeviationsSemantic proximity Read

UNRAVELing the synergistic effects of psilocybin and environment on brain-wide immediate early gene expression in miceSemantic proximity Read

Optogenetic activation of serotonergic neurons enhances anxiety-like behaviour in mice.Semantic proximity Read

Amplification and Suppression of Distinct Brain-wide Activity Patterns by CatecholaminesSemantic proximity Read

Probing the diversity of serotonin neurons.Semantic proximity Read

Identification of Serotonergic Neuronal Modules that Affect Aggressive Behavior.Semantic proximity Read

Genetically targeted reporter imaging of deep neuronal network in the mammalian brainSemantic proximity Read