Article
A polymer lab-on-a-chip for genetic analysis using the arrayed primer extension on microarray chips.
Biomedical microdevices - 1 Oct 2014
Marasso Simone L, Mombello Domenico, Cocuzza Matteo, Casalena Davide, Ferrante Ivan, Nesca Alessandro, Poiklik Piret, Rekker Kadri, Aaspollu Anu, Ferrero Sergio, Pirri Candido F
Abstract excerpt
In this work a polymer lab-on-a-chip (LOC), fabricated through MEMS technology, was employed to execute a genetic protocol for the Single Nucleotide Polymorphisms (SNPs) detection. The LOC was made in Poly (methyl methacrylate) (PMMA) and has two levels: the lower one for the insertion and mixing of the reagents, the upper one for the interfacing with the DNA microarray chip. The hereditary hearing loss was...
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