Article
Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer's disease.
Alzheimer's research & therapy - 30 Aug 2016
Blain Jean-François, Bursavich Matthew G, Freeman Emily A, Hrdlicka Lori A, Hodgdon Hilliary E, Chen Ting, Costa Don E, Harrison Bryce A, Kapadnis Sudarshan, Murphy Deirdre A, Nolan Scott, Tu Zhiming, Tang Cuyue, Burnett Duane A, Patzke Holger, Koenig Gerhard
Abstract excerpt
BACKGROUND: Familial Alzheimer's disease (FAD) is caused by mutations in the amyloid precursor protein (APP) or presenilin (PS). Most PS mutations, which account for the majority of FAD cases, lead to an increased ratio of longer to shorter forms of the amyloid beta (Aβ) peptide. The therapeutic rationale of γ-secretase modulators (GSMs) for Alzheimer's disease is based on this genetic evidence as well as on...
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