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Article

Efficient −2 frameshifting by mammalian ribosomes to synthesize an additional arterivirus protein

4 Oct 2012

Abstract excerpt

Programmed -1 ribosomal frameshifting (-1 PRF) is a gene-expression mechanism used to express many viral and some cellular genes. In contrast, efficient natural utilization of -2 PRF has not been demonstrated previously in eukaryotic systems. Like all nidoviruses, members of the Arteriviridae (a family of positive-stranded RNA viruses) express their replicase polyproteins pp1a and pp1ab from two long ORFs (1a and...

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PMID: 23043113
DOI: 10.1073/pnas.1211145109

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