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Article

Recurrent MYOD1 mutations in pediatric and adult sclerosing and spindle cell rhabdomyosarcomas: evidence for a common pathogenesis.

Genes, chromosomes & cancer - 1 Sept 2014

Agaram Narasimhan P, Chen Chun-Liang, Zhang Lei, LaQuaglia Michael P, Wexler Leonard, Antonescu Cristina R

Abstract excerpt

Sclerosing and spindle cell rhabdomyosarcoma (RMS) are rare types of RMS recently reclassified as a stand-alone pathologic entity, separate from embryonal RMS (ERMS). Although sclerosing and spindle cell RMS share clinical and morphologic features, a pathogenetic link based on shared molecular alterations has not been established. Spindle cell RMS in children have been associated with a less aggressive clinical...

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Source

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Identifiers

PMID: 24824843
DOI: 10.1002/gcc.22187
PMCID: PMC4108340

Genes

MYOD1
MDM2
NCOA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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