Article
MYOD1-mutant spindle cell and sclerosing rhabdomyosarcoma: an aggressive subtype irrespective of age. A reappraisal for molecular classification and risk stratification.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jan 2019
Agaram Narasimhan P, LaQuaglia Michael P, Alaggio Rita, Zhang Lei, Fujisawa Yumi, Ladanyi Marc, Wexler Leonard H, Antonescu Cristina R
Abstract excerpt
Sclerosing and spindle cell rhabdomyosarcoma is a rare histologic subtype, designated in the latest WHO classification as a stand-alone pathologic entity. Three genomic groups have been defined: an infantile subset of spindle cell rhabdomyosarcoma harboring VGLL2-related gene fusions, a MYOD1-mutant subset commonly associated with sclerosing morphology, and a subset lacking recurrent genetic abnormalities. In...
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