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Article

A Molecular Study of Pediatric Spindle and Sclerosing Rhabdomyosarcoma: Identification of Novel and Recurrent VGLL2-related Fusions in Infantile Cases.

The American journal of surgical pathology - 1 Feb 2016

Alaggio Rita, Zhang Lei, Sung Yun-Shao, Huang Shih-Chiang, Chen Chun-Liang, Bisogno Gianni, Zin Angelica, Agaram Narasimhan P, LaQuaglia Michael P, Wexler Leonard H, Antonescu Cristina R

Abstract excerpt

Sclerosing rhabdomyosarcoma (ScRMS) and spindle cell rhabdomyosarcoma (SRMS) have been recently reclassified as a stand-alone pathologic entity, separate from embryonal RMS. Genetically, a subset of the congenital cases display NCOA2 gene rearrangements, whereas tumors occurring in older children or adults harbor MYOD1 gene mutations with or without coexisting PIK3CA mutations. Despite these recent advances, a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26501226
DOI: 10.1097/PAS.0000000000000538
PMCID: PMC4712098

Genes

NCOA2
VGLL2
MYOD1
CITED2
SRF
TEAD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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A Molecular Study of Pediatric Spindle and Sclerosing Rhabdomyosarcoma: Identification of Novel and Recurrent VGLL2-related Fusions in Infantile Cases.PMID 26501226Read ↗

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