Article
Switching metal ion coordination and DNA Recognition in a Tandem CCHHC-type zinc finger peptide.
Inorganic chemistry - 15 Apr 2013
Besold Angelique N, Oluyadi Abdulafeez A, Michel Sarah L J
Abstract excerpt
Neural Zinc Finger Factor-1 (NZF-1) and Myelin Transcription Factor 1 (MyT1) are two homologous nonclassical zinc finger (ZF) proteins that are involved in the development of the central nervous system (CNS). Both NZF-1 and MyT1 contain multiple ZF domains, each of which contains an absolutely conserved Cys2His2Cys motif. All three cysteines and the second histidine have been shown to coordinate Zn(II); however,...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Cobalt
- DNA
- DNA-Binding Proteins
- Histidine
- Metals
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Nerve Tissue Proteins
- Peptides
- Protein Binding
- Rats
- Sequence Alignment
- Trans-Activators
- Transcription Factors