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Article

Analysis of cysteine and histidine residues required for zinc response of the transcription factor human MTF-1.

Biological & pharmaceutical bulletin - 1 Jan 2015

Suzuki Kaoru, Otsuka Fuminori, Yamada Hirotomo, Koizumi Shinji

Abstract excerpt

Metal responsive element (MRE)-binding transcription factor-1 (MTF-1) is a zinc finger (ZF) transcription factor that plays a key role in heavy metal homeostasis by regulating relevant genes in response to metals. MTF-1 is known to be activated by heavy metals such as Zn and Cd, but the mechanism of activation remains unclear. In the present study, Cys and His residues of human MTF-1 (hMTF-1), some of which may...

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PMID: 25832641
DOI: 10.1248/bpb.b14-00830

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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