Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Among developmental regulators, StuA but not BrlA is essential for penicillin V production in Penicillium chrysogenum.

Applied and environmental microbiology - 1 Feb 2011

Sigl Claudia, Haas Hubertus, Specht Thomas, Pfaller Kristian, Kürnsteiner Hubert, Zadra Ivo

Abstract excerpt

In filamentous fungi, secondary metabolism is often linked with developmental processes such as conidiation. In this study we analyzed the link between secondary metabolism and conidiation in the main industrial producer of the β-lactam antibiotic penicillin, the ascomycete Penicillium chrysogenum. Therefore, we generated mutants defective in two central regulators of conidiation, the transcription factors BrlA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatography, High Pressure Liquid
Share to Culture Media

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fungal Proteins

Share to Gene Expression Regulation, Fungal

Share to Hyphae

Share to Multigene Family

Share to Spores, Fungal

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 21148688
DOI: 10.1128/AEM.01557-10
PMCID: PMC3028705

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Among developmental regulators, StuA but not BrlA is essential for penicillin V production in Penicillium chrysogenum.PMID 21148688Read ↗

Impact of velvet complex on transcriptome and penicillin G production in glucose-limited chemostat cultures of a β-lactam high-producing Penicillium chrysogenum strain.Semantic proximity Read ↗

PcchiB1, encoding a class V chitinase, is affected by PcVelA and PcLaeA, and is responsible for cell wall integrity in Penicillium chrysogenum.Semantic proximity Read ↗

Molecular Regulation of β-Lactam Biosynthesis in Filamentous FungiSemantic proximity Read ↗

Manipulation of fungal development as source of novel secondary metabolites for biotechnology.Semantic proximity Read ↗

cpsA regulates mycotoxin production, morphogenesis and cell wall biosynthesis in the fungus Aspergillus nidulans.Semantic proximity Read ↗

Members of the Penicillium chrysogenum velvet complex play functionally opposing roles in the regulation of penicillin biosynthesis and conidiation.Semantic proximity Read ↗

An LaeA- and BrlA-Dependent Cellular Network Governs Tissue-Specific Secondary Metabolism in the Human Pathogen Aspergillus fumigatusSemantic proximity Read ↗

Transcriptional profiling identifies a role for BrlA in the response to nitrogen depletion and for StuA in the regulation of secondary metabolite clusters in Aspergillus fumigatus.Semantic proximity Read ↗

Direct involvement of the CreA transcription factor in penicillin biosynthesis and expression of the pcbAB gene in Penicillium chrysogenum.Semantic proximity Read ↗

BldD, a master developmental repressor, activates antibiotic production in two Streptomyces speciesSemantic proximity Read ↗

Key role of LaeA and velvet complex proteins on expression of β-lactam and PR-toxin genes in Penicillium chrysogenum: cross-talk regulation of secondary metabolite pathways.Semantic proximity Read ↗

The global regulator LaeA controls penicillin biosynthesis, pigmentation and sporulation, but not roquefortine C synthesis in Penicillium chrysogenum.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.