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Article

RNA-silencing in Penicillium chrysogenum and Acremonium chrysogenum: validation studies using beta-lactam genes expression.

Journal of microbiological methods - 1 Oct 2008

Ullán Ricardo V, Godio Ramiro P, Teijeira Fernando, Vaca Inmaculada, García-Estrada Carlos, Feltrer Raúl, Kosalkova Katarina, Martín Juan F

Abstract excerpt

In this work we report the development and validation of a new RNA interference vector (pJL43-RNAi) containing a double-stranded RNA expression cassette for gene silencing in the filamentous fungi Penicillium chrysogenum and Acremonium chrysogenum. Classical targeted gene disruption in these fungi is very laborious and inefficient due to the low frequency of homologous recombination. The RNAi vector has been...

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Identifiers

PMID: 18590779
DOI: 10.1016/j.mimet.2008.06.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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