Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Principles of analytical validation of next-generation sequencing based mutational analysis for hematologic neoplasms in a CLIA-certified laboratory.

Expert review of molecular diagnostics - 1 Jan 2016

Kanagal-Shamanna Rashmi, Singh Rajesh R, Routbort Mark J, Patel Keyur P, Medeiros L Jeffrey, Luthra Rajyalakshmi

Abstract excerpt

Targeted therapy based on mutational profiles is the current standard of practice for the management of patients with hematologic malignancies. Next-generation sequencing (NGS)- based analysis has been adopted by clinical laboratories for high-throughput mutational profiling of myeloid and lymphoid neoplasms. The technology is fairly novel and complex, hence both validation and test implementation in a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hematologic Neoplasms

Share to High-Throughput Nucleotide Sequencing

Share to Molecular Diagnostic Techniques

Share to Mutation

Share to Sequence Analysis, DNA

Share to Validation Studies as Topic

Source

Identifiers

PMID: 26765348
DOI: 10.1586/14737159.2016.1142374

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Principles of analytical validation of next-generation sequencing based mutational analysis for hematologic neoplasms in a CLIA-certified laboratory.PMID 26765348Read ↗

Applications of next-generation sequencing in hematologic malignancies.Semantic proximity Read ↗

The role of next-generation sequencing in hematologic malignanciesSemantic proximity Read ↗

Current practices and guidelines for clinical next-generation sequencing oncology testing.Semantic proximity Read ↗

Clinical Validation of a Targeted Next-Generation Sequencing Panel for Lymphoid Malignancies.Semantic proximity Read ↗

Next‐generation sequencing – feasibility and practicality in haematologySemantic proximity Read ↗

Integration of next-generation sequencing in clinical diagnostic molecular pathology laboratories for analysis of solid tumours; an expert opinion on behalf of IQN Path ASBL.Semantic proximity Read ↗

Routine next generation sequencing of lymphoid malignancies: clinical utility and challenges from a 3-Year practical experience.Semantic proximity Read ↗

Implementation of an NGS‐based sequencing and gene fusion panel for clinical screening of patients with suspected hematologic malignanciesSemantic proximity Read ↗

Validation and Implementation of a Custom Next-Generation Sequencing Clinical Assay for Hematologic Malignancies.Semantic proximity Read ↗

Analytical Validation of an Automated Semiconductor-Based Next-Generation Sequencing Assay for Detection of DNA and RNA Alterations in Myeloid Neoplasms.Semantic proximity Read ↗

A Canadian Guideline on the Use of Next-Generation Sequencing in OncologySemantic proximity Read ↗

Next-generation sequencing for lymphoid neoplasms: Real-world utility from a clinical assay.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.