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Principles of analytical validation of next-generation sequencing based mutational analysis for hematologic neoplasms in a CLIA-certified laboratory.

Expert review of molecular diagnostics - 1 Jan 2016

Kanagal-Shamanna Rashmi, Singh Rajesh R, Routbort Mark J, Patel Keyur P, Medeiros L Jeffrey, Luthra Rajyalakshmi

Abstract excerpt

Targeted therapy based on mutational profiles is the current standard of practice for the management of patients with hematologic malignancies. Next-generation sequencing (NGS)- based analysis has been adopted by clinical laboratories for high-throughput mutational profiling of myeloid and lymphoid neoplasms. The technology is fairly novel and complex, hence both validation and test implementation in a...

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Acute Myeloid Leukemia Research
Biomarkers, Tumor
Hematologic Neoplasms
High-Throughput Nucleotide Sequencing
Molecular Diagnostic Techniques

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Sequence Analysis, DNA

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PMID: 26765348
DOI: 10.1586/14737159.2016.1142374

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