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Article

Casein kinase II regulation of the Hot1 transcription factor promotes stochastic gene expression.

The Journal of biological chemistry - 20 Jun 2014

Burns Laura T, Wente Susan R

Abstract excerpt

In Saccharomyces cerevisiae, Hog1 MAPK is activated and induces a transcriptional program in response to hyperosmotic stress. Several Hog1-responsive genes exhibit stochastic transcription, resulting in cell-to-cell variability in mRNA and protein levels. However, the mechanisms governing stochastic gene activity are not fully defined. Here we uncover a novel role for casein kinase II (CK2) in the cellular...

Topics

Casein Kinase II
Gene Expression Regulation, Fungal
Membrane Transport Proteins
Mitogen-Activated Protein Kinases
Mutation
Osmotic Pressure
Phosphorylation
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Stochastic Processes

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Identifiers

PMID: 24817120
DOI: 10.1074/jbc.M114.561217
PMCID: PMC4067201

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-24817120-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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