Article
mPGES1-Dependent Prostaglandin E2 (PGE2) Controls Antigen-Specific Th17 and Th1 Responses by Regulating T Autocrine and Paracrine PGE2 Production.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2018
Maseda Damian, Johnson Elizabeth M, Nyhoff Lindsay E, Baron Bridgette, Kojima Fumiaki, Wilhelm Ashley J, Ward Martin R, Woodward Jerold G, Brand David D, Crofford Leslie J
Abstract excerpt
The integration of inflammatory signals is paramount in controlling the intensity and duration of immune responses. Eicosanoids, particularly PGE2, are critical molecules in the initiation and resolution of inflammation and in the transition from innate to acquired immune responses. Microsomal PGE synthase 1 (mPGES1) is an integral membrane enzyme whose regulated expression controls PGE2 levels and is highly...
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