FLT1 genetic variation predisposes to neovascular AMD in ethnically diverse populations and alters systemic FLT1 expression.

doi:10.1167/iovs.14-14047

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Article

FLT1 genetic variation predisposes to neovascular AMD in ethnically diverse populations and alters systemic FLT1 expression.

Investigative ophthalmology & visual science - 8 May 2014

Owen Leah A, Morrison Margaux A, Ahn Jeeyun, Woo Se Joon, Sato Hajime, Robinson Rosann, Morgan Denise J, Zacharaki Fani, Simeonova Marina, Uehara Hironori, Chakravarthy Usha, Hogg Ruth E, Ambati Balamurali K, Kotoula Maria, Baehr Wolfgang, Haider Neena B, Silvestri Giuliana, Miller Joan W, Tsironi Evangelia E, Farrer Lindsay A, Kim Ivana K, Park Kyu Hyung, DeAngelis Margaret M

Abstract excerpt

PURPOSE: Current understanding of the genetic risk factors for age-related macular degeneration (AMD) is not sufficiently predictive of the clinical course. The VEGF pathway is a key therapeutic target for treatment of neovascular AMD; however, risk attributable to genetic variation within pathway genes is unclear. We sought to identify single nucleotide polymorphisms (SNPs) associated with AMD within the VEGF...

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Identifiers

PMID: 24812550
DOI: 10.1167/iovs.14-14047
PMCID: PMC4073997

Genes

FLT1
KDR
VASH1
VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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