Association between CFH, CFB, ARMS2, SERPINF1, VEGFR1 and VEGF polymorphisms and anatomical and functional response to ranibizumab treatment in neovascular age-related macular degeneration.

doi:10.1111/aos.13519

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Article

Association between CFH, CFB, ARMS2, SERPINF1, VEGFR1 and VEGF polymorphisms and anatomical and functional response to ranibizumab treatment in neovascular age-related macular degeneration.

Acta ophthalmologica - 1 Mar 2018

Cobos Estefania, Recalde Sergio, Anter Jaouad, Hernandez-Sanchez Maria, Barreales Carla, Olavarrieta Leticia, Valverde Alicia, Suarez-Figueroa Marta, Cruz Fernando, Abraldes Maximino, Pérez-Pérez Julian, Fernández-Robredo Patricia, Arias Luis, García-Layana Alfredo

Abstract excerpt

PURPOSE: We sought to determine if specific genetic single nucleotide polymorphisms (SNPs) influence vascular endothelial growth factor inhibition response to ranibizumab in neovascular age-related macular degeneration (AMD). METHODS: A total of 403 Caucasian patients diagnosed with exudative AMD were included. After a three-injection loading phase, a pro re nata regimen was followed. Nine SNPs from six different...

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Identifiers

PMID: 28926193
DOI: 10.1111/aos.13519

Genes

CFB
CFH
SERPINF1
ARMS2
VEGFA

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