Article
Cumulative effects of variants identified by genome-wide association studies in IgA nephropathy.
Scientific reports - 9 May 2014
Zhou Xu-Jie, Qi Yuan-Yuan, Hou Ping, Lv Ji-Cheng, Shi Su-Fang, Liu Li-Jun, Zhao Na, Zhang Hong
Abstract excerpt
The effect of genetic markers associated with IgA nephropathy on risk of disease in sub-phenotype and progression is uncertain. Data from 2096 Chinese patients were used to create both un-weighted (uw) and weighted (w) genetic risk score (GRS). The association between GRS with disease susceptibility and clinical parameters were assessed. All nine selected single nucleotide polymorphisms (SNPs) were associated...
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