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Article

Enhancement of DNA vaccine potency against legumain.

Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Jun 2014

Smahel Michal, Duskova Martina, Polakova Ingrid, Musil Jan

Abstract excerpt

The asparaginyl endopeptidase legumain that is overexpressed in M2-polarized tumor-associated macrophages has been identified as a suitable target for elimination of these cells supporting tumor progression. To enhance the efficacy of DNA immunization against legumain, we performed several modifications in this protein that could improve induction of immune responses. First, we mutated the RGD motif into GGD or...

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Identifiers

PMID: 24810641
DOI: 10.1097/CJI.0000000000000040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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