Article
Mutational heterogeneity in cancer and the search for new cancer-associated genes.
Nature - 11 Jul 2013
Lawrence Michael S, Stojanov Petar, Polak Paz, Kryukov Gregory V, Cibulskis Kristian, Sivachenko Andrey, Carter Scott L, Stewart Chip, Mermel Craig H, Roberts Steven A, Kiezun Adam, Hammerman Peter S, McKenna Aaron, Drier Yotam, Zou Lihua, Ramos Alex H, Pugh Trevor J, Stransky Nicolas, Helman Elena, Kim Jaegil, Sougnez Carrie, Ambrogio Lauren, Nickerson Elizabeth, Shefler Erica, Cortés Maria L, Auclair Daniel, Saksena Gordon, Voet Douglas, Noble Michael, DiCara Daniel, Lin Pei, Lichtenstein Lee, Heiman David I, Fennell Timothy, Imielinski Marcin, Hernandez Bryan, Hodis Eran, Baca Sylvan, Dulak Austin M, Lohr Jens, Landau Dan-Avi, Wu Catherine J, Melendez-Zajgla Jorge, Hidalgo-Miranda Alfredo, Koren Amnon, McCarroll Steven A, Mora Jaume, Crompton Brian, Onofrio Robert, Parkin Melissa, Winckler Wendy, Ardlie Kristin, Gabriel Stacey B, Roberts Charles W M, Biegel Jaclyn A, Stegmaier Kimberly, Bass Adam J, Garraway Levi A, Meyerson Matthew, Golub Todd R, Gordenin Dmitry A, Sunyaev Shamil, Lander Eric S, Getz Gad
Abstract excerpt
Major international projects are underway that are aimed at creating a comprehensive catalogue of all the genes responsible for the initiation and progression of cancer. These studies involve the sequencing of matched tumour-normal samples followed by mathematical analysis to identify those genes in which mutations occur more frequently than expected by random chance. Here we describe a fundamental problem with...
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