Zfy gene expression patterns are not compatible with a primary role in mouse sex determination.

Abstract excerpt

The Y chromosome determines maleness in mammals. A Y chromosome-linked gene diverts the indifferent embryonic gonad from the default ovarian pathway in favour of testis differentiation, initiating male development. Study of this basic developmental switch requires the isolation of the testis-determining gene, termed TDF in humans and Tdy in mice. ZFY, a candidate gene for TDF, potentially encodes a zinc-finger...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Base Sequence
• Share to Blotting, Northern
• Share to Gene Expression