Article
Zfy gene expression patterns are not compatible with a primary role in mouse sex determination.
Nature - 1 Jan 2000
Koopman P, Gubbay J, Collignon J, Lovell-Badge R
Abstract excerpt
The Y chromosome determines maleness in mammals. A Y chromosome-linked gene diverts the indifferent embryonic gonad from the default ovarian pathway in favour of testis differentiation, initiating male development. Study of this basic developmental switch requires the isolation of the testis-dete...
Topics
- Animals
- Base Sequence
- Blotting, Northern
- Embryo, Mammalian
- Female
- Gene Amplification
- Gene Expression
- Male
- Mice
- Molecular Sequence Data
- Ovary
- Phenotype
- RNA
- RNA Splicing
- Sex Determination Analysis
- Testis
- Transcription, Genetic
- Y Chromosome