Normal structure and expression of Zfy genes in XY female mice mutant in Tdy.

Abstract excerpt

Zfy-1 and Zfy-2 are candidate genes for Tdy, the testis-determining gene in mice. We have analysed these genes in a line of XY female mice that have been shown to be mutated in Tdy. We have used Southern blot analysis to show that the Zfy genes have not undergone any major structural alterations, and have also demonstrated that both genes are transcribed normally from the mutant Y chromosome (Y) in both adult XYY...

Topics

• Animals
• DNA
• Female
• Gene Expression
• Genes
• Male
• Mice
• Molecular Sequence Data
• Mutation
• RNA
• Sex Chromosome Aberrations
• Sex Determination Analysis