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Article

A novel multiplex pyrosequencing assay for genotyping functionally relevant CTLA-4 polymorphisms: potential applications in autoimmunity and cancer.

Human immunology - 1 Aug 2014

Banelli Barbara, Morabito Anna, Laurent Stefania, Piccioli Patrizia, Dozin Beatrice, Ghio Massimo, Ascierto Paolo Antonio, Monteghirfo Stefano, Marasco Antonella, Ottaviano Vincenzo, Queirolo Paola, Romani Massimo, Pistillo Maria Pia

Abstract excerpt

CTLA-4 expression/function can be affected by single nucleotide polymorphisms (SNPs) of CTLA-4 gene, which have been widely associated with susceptibility or progression to autoimmune diseases and cancer development. In this study, we analyzed six CTLA-4 SNPs (-1661A>G, -1577G>A, -658C>T, -319C>T, +49A>G, CT60G>A) in 197 DNA samples from 43 B-lymphoblastoid cell lines (B-LCLs), 40 systemic sclerosis (SSc)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24801647
DOI: 10.1016/j.humimm.2014.04.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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