Article
Development of multiplex pyrosequencing for HLA-B*57:01 screening using single nucleotide polymorphism haplotype.
Journal of clinical pharmacy and therapeutics - 1 Oct 2014
Sankuntaw N, Chantarangsu S, Chantratita W, Sungkanuparph S, Kiertiburanakul S, Lulitanond V
Abstract excerpt
WHAT IS KNOWN AND OBJECTIVE: Abacavir (ABC) is a commonly used nucleoside reverse-transcriptase inhibitor with potent antiviral activity against HIV-1. The US Food and Drug Administration and international HIV treatment guidelines recommend HLA-B*57:01 screening before initiating treatment with ABC. The current standard method for HLA-B*57:01 screening is limited by its high-cost, time-consuming and...
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