Effects of CTLA-4 Single Nucleotide Polymorphisms on Toxicity of Ipilimumab-Containing Regimens in Patients With Advanced Stage Melanoma.

doi:10.1097/CJI.0000000000000506

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Article

Effects of CTLA-4 Single Nucleotide Polymorphisms on Toxicity of Ipilimumab-Containing Regimens in Patients With Advanced Stage Melanoma.

Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Jun 2024

de Joode Karlijn, Mora Alfonso Rojas, van Schaik Ron H N, Zippelius Alfred, van der Veldt Astrid, Gerard Camille Léa, Läubli Heinz, Michielin Olivier, von Moos Roger, Joerger Markus, Levesque Mitchell P, Aeppli Stefanie, Mangana Johanna, Mangas Cristina, Trost Nadine, Meyer Stefan, Parvex Sandra Leoni, Mathijssen Ron, Metaxas Yannis

Abstract excerpt

Single nucleotide polymorphisms (SNPs) in the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) gene, an inhibitor of T-cell priming, are associated with auto and alloimmunity. Studies implied a role for these SNPs as surrogate markers for immunotherapy-outcome in patients with melanoma. However, no predictive SNPs are defined to date. We analyzed different CTLA-4 SNPs in a large multicenter cohort of patients...

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PMID: 38318726
DOI: 10.1097/CJI.0000000000000506

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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