Article
Mutation of mouse Samd4 causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling.
Proceedings of the National Academy of Sciences of the United States of America - 20 May 2014
Chen Zhe, Holland William, Shelton John M, Ali Aktar, Zhan Xiaoming, Won Sungyong, Tomisato Wataru, Liu Chen, Li Xiaohong, Moresco Eva Marie Y, Beutler Bruce
Abstract excerpt
Sterile alpha motif domain containing protein 4 (Samd4) is an RNA binding protein that mediates translational repression. We identified a Samd4 missense mutation, designated supermodel, that caused leanness and kyphosis associated with myopathy and adipocyte defects in C57BL/6J mice. The supermod...
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