Article
The Sam68 STAR RNA-binding protein regulates mTOR alternative splicing during adipogenesis.
Molecular cell - 27 Apr 2012
Huot Marc-Étienne, Vogel Gillian, Zabarauskas Amber, Ngo Chau Tuan-Anh, Coulombe-Huntington Jasmin, Majewski Jacek, Richard Stéphane
Abstract excerpt
We report that mice ablated for the Sam68 RNA-binding protein exhibit a lean phenotype as a result of increased energy expenditure, decreased commitment to early adipocyte progenitors, and defects in adipogenic differentiation. The Sam68(-/-) mice were protected from obesity, insulin resistance, and glucose intolerance induced with a high-fat diet. To identify the alternative splice events regulated by Sam68,...
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