Clostridial pore-forming toxins: powerful virulence factors.

doi:10.1016/j.anaerobe.2014.05.014

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Article

Clostridial pore-forming toxins: powerful virulence factors.

Anaerobe - 1 Dec 2014

Popoff Michel R

Abstract excerpt

Pore formation is a common mechanism of action for many bacterial toxins. More than one third of clostridial toxins are pore-forming toxins (PFTs) belonging to the β-PFT class. They are secreted as soluble monomers rich in β-strands, which recognize a specific receptor on target cells and assemble in oligomers. Then, they undergo a conformational change leading to the formation of a β-barrel, which inserts into...

Topics

Bacterial Toxins
Cell Membrane
Clostridium
Evolution, Molecular
Genetic Variation
Intracellular Membranes
Pore Forming Cytotoxic Proteins
Virulence Factors

Source

Open in PubMed

Identifiers

PMID: 24952276
DOI: 10.1016/j.anaerobe.2014.05.014

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