Article
A fast and powerful tree-based association test for detecting complex joint effects in case-control studies.
Bioinformatics (Oxford, England) - 1 Aug 2014
Zhang Han, Wheeler William, Wang Zhaoming, Taylor Philip R, Yu Kai
Abstract excerpt
MOTIVATION: Multivariate tests derived from the logistic regression model are widely used to assess the joint effect of multiple predictors on a disease outcome in case-control studies. These tests become less optimal if the joint effect cannot be approximated adequately by the additive model. The tree-structure model is an attractive alternative, as it is more apt to capture non-additive effects. However, the...
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